GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs30187 | 1 | rs469758 | chr5:96121715 | ERAP1 | chr5:96096515-96149837:- | -0.32 | -4.13 | 7.77E-5 | Ankylosing spondylitis |
| THYM | cis | rs1577917 | 1 | rs4706254 | chr6:86602813 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs4707239 | chr6:86610717 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs9457247 | 1 | rs4710147 | chr6:167374239 | RNASET2 | chr6:167343008-167412795:- | 0.47 | 7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs7849270 | 1 | rs4713 | chr9:131910805 | CRAT | chr9:131857075-131873070:- | -0.42 | -4.98 | 2.82E-6 | Blood metabolite ratios |
| THYM | cis | rs9473555 | 1 | rs4715129 | chr6:49415043 | CENPQ | chr6:49431096-49460820:+ | -0.23 | -4.24 | 5.16E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs4715129 | chr6:49415043 | MUT | chr6:49398994-49431031:- | 0.28 | 4.43 | 2.56E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs4715130 | chr6:49416825 | CENPQ | chr6:49431096-49460820:+ | -0.23 | -4.18 | 6.53E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs4715130 | chr6:49416825 | MUT | chr6:49398994-49431031:- | 0.28 | 4.37 | 3.17E-5 | Folate pathway vitamin levels |
| THYM | cis | rs2243480 | 1 | rs4718269 | chr7:65200778 | CCT6P1 | chr7:65216092-65228661:+ | -0.69 | -5.71 | 1.31E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs4718270 | chr7:65202407 | CCT6P1 | chr7:65216092-65228661:+ | 0.74 | 5.74 | 1.13E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs4718309 | chr7:65627764 | CCT6P1 | chr7:65216092-65228661:+ | -0.65 | -5.41 | 4.64E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs4718315 | chr7:65648541 | CCT6P1 | chr7:65216092-65228661:+ | -0.67 | -5.68 | 1.48E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs4718316 | chr7:65648731 | CCT6P1 | chr7:65216092-65228661:+ | -0.67 | -5.68 | 1.48E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs4718317 | chr7:65648901 | CCT6P1 | chr7:65216092-65228661:+ | -0.67 | -5.68 | 1.48E-7 | Diabetic kidney disease |